Oh, I didn't understood your question at first.
I looked it up after Digibro recced it in his top 20 anime list honourable mentions, so I went almost blindly into it and was thoroughly impressed by result.
It features stereotypes, but it throughly breaks and plays with them, that is surpising and pleasant for japanese show, it's about girls, but feels, that it could've been about boys, just as easily, it's respectful and dignified, while toes on thin line between comical, heartwarming, informative, earnest, uncomfortable, awkward and sexual (and isn't afraid of any of those), but timing and pacing is so great, that it falls completely into one of those.
It doesn't have transgender aspect. I just like the healthy environmemt it emanated/propagated and found it informative. I mean, there's clearly a lot of stuff, most guys don't know (well, I don't or didn't know) about girls and women, that are never explained under umbrella of 'girl things'. and 'girl talk'.
Information, that is integral to interpersonal communication and relatability and sometimes, just bizarre and funny. A lot of failed and uhappily married couple I know of stem from utter inability and reluctance to see/open up beyond projected masks and formed stereotypes, regardless of what those stereotypes are...
O the grand scale of things, this anime it's decent and nice little thing about girls, I liked, but life is composed of small moments. So.. yeah.
(Youtube channel/personality: Digibro is surprisingly non-creepy version of cute anime girl, but guy with a beard; I mean look at his eyes, it's a cartoon in human skin! If you're into anime and anime critique, that is)